Talk:Progesterone

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Video Talk:Progesterone

Edit request on 1 March 2012

I apparently just did this simple procedure incorrectly, either way, I have been editing on here for a long time and it has been as of only recently that I have to go through these barriers to get my requests approved. In any event, as I mentioned previously, I am conducting research independent-from any university although I have my neuroscience professor supervising me and I wanted to publish some of the findings about progesterone's effectiveness in treating traumatic brain injury. It was recently approved for phase III of clinical trials, and I plan to point this fact out first before offering any definitive conclusions about the results. However, TBI, (traumatic brain injury) look up how common it is, according to the CDC "TBI is a contributing factor in 30.5% of all injury-related deaths in the United States and responsible for a mind blowing estimated $76.5 billion in the United States in 2000" and recent statistics find that the injury rate is upwards of 3 million a year. Mind you this includes people with concussions, however, this is also to say that people with these "simple" brain injuries could have access to better health care options. This is not your typical, media makes a big announcement about a potential break through and a person makes a run with it and then everyone is interested. In fact, so far the opposite.

In a attempt to reinforce why I should be allowed t post and edit at will, one because I am far more scared to post anything slightly irrefutable than anyone else I am about to publish my first real article and I am still only an undergraduate. Point is that this treatment saves lives, and those who are injured and receive treatment are in better positions to heal and regain function faster. The fact is, whether you (whoever in the hell edits these things, its wikipedia for Christs sake) will sadly or have known someone to fall down their stairs and hit their head, have a son or daughter get a concussion in school sports, or god forbid receive a head injury from a road side bomb while serving in Iraq or Afghanistan. Guess I will attempt to make an impression here and add a quote and a reference, not in the specified manor but for credibility safe, -According to Representative Bill Pascrell (Democrat, NJ), TBI is "the signature injury of the wars in Iraq and Afghanistan." And, according to The Pentagon "Congress [Is] Studying Brain-Damage Therapy". ProPublica. Retrieved 2011-01-23. "Brave Americans who risked everything for their country and sustained traumatic brain injuries -- the signature injury of the wars in Iraq and Afghanistan -- deserve cognitive rehabilitation therapy to help them secure the best futures possible. It is unacceptable that the United States has been at war for nearly a decade and there is still no plan to treat these soldiers."

If I even now decided to stay up longer and go into the results of the findings, you would be so blown away, you would most likely contact me or the lead research directly. The fact is, 1) if you go on pubmed there are some 214 articles published on the entire matter I believe, 2) these articles do not come close to displaying the results that I have independently confirmed in my own studies, and 3, we are at the vanguard of a medical treatment that for over the last 20 years has been static. The most disappointing thing for me is that instead of being presented by wikipedia the time and opportunity to collectively get my ideas, thoughts, and arguments down in a manner that is persuasive yet unbiasis, educational yet straight forward, and cost effective. I just wasted all my time writing this hopefully persuasive cover letter to allow me to avoid such time onsuming restrictions and post my finishing points starting over spring break in a cohesive and summarizing manor, that I am still able to conclude my research and work to publish my results. Ill get started on typing up the actual research when it seems to be.

Sam

Srut07 (talk) 07:48, 1 March 2012 (UTC)

We can not publish preliminary findings from research that has not been published yet. What you can do is to summarize everything that has been published so far and mention the phase III trial that is in progress. Try to create a draft in your userspace so we can get an idea. Richiez (talk) 10:42, 1 March 2012 (UTC)

Maps Talk:Progesterone

Cleanup progesteron vs progestin effects/adverse effects

Seems the distinction could be clearer. Progestins are so diverse that trying to cover their effects in this article will bring only confusion. Richiez (talk) 21:56, 5 March 2012 (UTC)

Section to a specific product and source is dead:

src: i.ytimg.com

Percy Lavon Julian trivia paragraph and copyright violation paragraph

I removed a trivia paragraph about Percy Lavon Julian and a WP:COPYVIO paragraph (about Mexican wild yams no longer being used in 1995 to produce progesterone) added to the Plants section by IP-hopping anonymous editor 71.123.25.175 (aka 141.149.208.54 / 71.123.29.191 / 71.182.123.65 / 71.123.17.215 / 71.182.107.102 / 70.16.52.193 / 70.16.61.75 / 71.182.100.111 / 71.240.244.35 / 71.123.31.25 / 71.240.247.110 / 70.16.49.248 / 71.182.108.43 / 71.182.98.194 / 71.182.111.225):

taken from:

Lynn4 (talk) 19:55, 16 April 2012 (UTC)

src: lionsbahari.com

Editing again...

I had submitted edits before to this page, and Richiez recommended I create a draft in my userspace. I did this but the editor told me that since the page already existed that I could just go ahead and make the changes myself. I would love to do this, however the page is semi-protected and thus I can not at this time. To avoid wasting any more time trying to do it myself I just thought I would post the additional information to add here in hopes that some administrator would just go ahead and add it. Thank you, information and sources to follow.

Thank you and I look forward to seeing these changes made whenever possible and this page becoming unprotected. -- Preceding unsigned comment added by Srut12 (talk o contribs) 21:37, 28 April 2012 (UTC)

Hi. Thank you for your contribution. Per WP:MEDRS, citations to human clinical results must use secondary sources (i.e., review articles or meta-studies). In references 1-4, only reference 4 is a secondary source. Another review article that you have not cited, PMID 21497181, looks relevant. Can you modify this section so that it only cites secondary sources?

The source requirements for animal studies are not quite as strict (see WP:SCIRS), but even here, secondary sources are preferred and none of the sources that you have provided are secondary. Can you identify any review articles that could replace primary sources? Here are some possibilities. Boghog (talk) 22:28, 28 April 2012 (UTC)

I assume this would come as a subsection of "Brain damage" ? My idea is to start with the animal studies, something like "Animal studies have indicated potential use in traumatic brain injury. In experimental animal models of traumatic brain injury progesterone has been shown to be able to cross the blood brain barrier,[5] reduce edema formation[6], modulate the expression of molecules implicated in edema formation,[7] reduce ischemic conditions by protecting against lipid peroxidation,[8] reduce inflammation[9] as well as reduce the production of pro-inflammtory cytokines,[10,11] and to reduce excitotoxicty induced neuronal death.[12]. Subsequent human phase I and II trials did show some promise and phase III trials (ProTECT III: NCT00822900, SyNAPSe: NCT01143064) were initiated.(eg ref PMID 21035878)."

Yes, you can be more verbose, was just a very quick draft. But for now I would leave out most or all details such as iv administration and focus on content that is likely to stay regardless of the results of the ongoing trials. Also the progesterone article should be mostly focused on mechanism of action while treatment details would go to TBI once there are good enough sources. Richiez (talk) 18:27, 29 April 2012 (UTC)

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Edit Request for Section on Brain Injury

I'm an undergraduate student studying biomedical engineering at Georgia Tech currently taking a senior level course in neuroscience. As an assignment, we were to edit a Wikipedia article, and I chose Progesterone as a treatment for TBI. I am requesting editing privileges for this article to edit the section on Brain Injury. Below is the included section edits along with their citations and I will add links to other articles after I am permitted to add what I've included:

E.K.Woodall (talk) 19:25, 12 July 2012? (UTC)

Hi. Thanks for your contributions. Have you read the above section? Per WP:SECONDARY, secondary sources are strongly preferred. Of the citations that you have selected only #8 (PMID 21497181) is a secondary source. The others are all primary sources. If you had chosen citations from this list, things would have been much simpler. I would appreciate if you would go through your list of citations and substitute primary with secondary sources where ever possible. Thanks. Boghog (talk) 19:15, 12 July 2012 (UTC)

If you haven't seen this yet, please check out User:Diberri's Wikipedia template filling tool (instructions). Given a PubMed ID, one can quickly produce a full citation that can be copied and pasted into a Wikipedia article. This tool can save you a lot of work and ensure that the citations are displayed in a consistent manner. Boghog (talk) 20:39, 12 July 2012 (UTC)

I replaced primary sources for secondary sources where I could and added some more to mechanism but only using reviews. E.K.Woodall (talk) 2:48, 19 July 2012? (UTC)

 Done Nice work! Thank you for your contribution. Your text has now been added to the article. There was already a short section on brain damage, so I tried to integrate your text with the previous text. The section probably needs a bit more editing to remove some redundancy between the previous text and your text, but I think the present version is in reasonably good shape. Cheers. Boghog (talk) 06:54, 19 July 2012 (UTC)

src: pbs.twimg.com

Progesterone-Multiple Sclerosis Link

Hello.

Could you provide more information on the possible link between MS and progesterone, and what possible citations there might be for stating that in your article. I am a 36yo male, and I am curious if that link could be proven, not only for females, but males also, given the studies that males and females have the same levels of progesterone in their bodies, and if I read your article right, higher levels during pregnancy.

Thank you.

Traumaemt99 (talk) 00:31, 7 June 2013 (UTC)

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Why does "corporin" redirect here?

Not mentioned in article. Is it a trade name? 86.159.197.174 (talk) 04:33, 22 August 2014 (UTC)

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Why does "luteol" redirect here?

Term not used in text. 81.159.93.150 (talk) 17:02, 7 March 2015 (UTC)

Same question for "luteohormone", which also redirects here. 81.159.93.150 (talk) 17:04, 7 March 2015 (UTC)

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Moved from article

I have moved the following content here because it lacks context/explanation. If anyone wants to use it to improve the article, here it is. -- Ed (Edgar181) 14:47, 17 September 2015 (UTC)

The last reaction shows an [[Oppenauer oxidation]] of [[pregnenolone]] to progesterone. [[File:Progesterone synthesis.png|thumb|400px|left|Progesterone synthesis:<ref name=Heyl/><ref>{{Cite journal | doi = 10.1002/recl.19370560206| title = Eine Methode der Dehydrierung von Sekundären Alkoholen zu Ketonen. I. Zur Herstellung von Sterinketonen und Sexualhormonen| journal = Recueil des Travaux Chimiques des Pays-Bas| volume = 56| issue = 2| pages = 137| year = 2010| last1 = Oppenauer | first1 = R. V.}}</ref><ref>{{Cite journal | doi = 10.1021/ja01610a036| title = A Synthesis of Progesterone from Ergosterol1| journal = Journal of the American Chemical Society| volume = 77| issue = 5| pages = 1212| year = 1955| last1 = Shepherd | first1 = D. A.| last2 = Donia | first2 = R. A.| last3 = Campbell | first3 = J. A. | last4 = Johnson | first4 = B. A.| last5 = Holysz | first5 = R. P.| last6 = Slomp | first6 = G.| last7 = Stafford | first7 = J. E.| last8 = Pederson | first8 = R. L.| last9 = Ott | first9 = A. C.}}</ref> {{US patent|2379832}} {{US patent|2379832}} {{US patent|2232438}} {{US patent|2420489}}]]

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Split

Should we split into progesterone and progesterone (medication)? Doc James (talk · contribs · email) 01:30, 20 November 2016 (UTC)

src: slideplayer.com

P4

Can someone explain the meaning of (P4) at the top of this article?

Simon de Danser (talk) 10:22, 23 June 2017 (UTC)

Nope, removed. Jytdog (talk) 13:33, 23 June 2017 (UTC)

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External links modified

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